By J.W. Gorrod, P. Jacob III
This ebook offers for the 1st time a unmarried complete resource of data at the analytical chemistry of nicotine and comparable alkaloids. The editors have introduced jointly scientists from academia and the tobacco to explain the cutting-edge of the chemistry and analytical equipment for dimension of nicotine. either the scope and element of the booklet are remarkable. Chapters describe the heritage, pharmacology and toxicology of nicotine, the biosynthesis of nicotine and different alkaloids within the tobacco plant, the overall chemistry of nicotine and the analytical methodologies which have been used to degree nicotine and comparable alkaloids in organic specimens, in tobacco and pharmaceutical items and in tobacco smoke. there's additionally a entire evaluation of the chemistry and toxicology of nicotine-derived nitrosamines, a tremendous classification of tobacco cancer causing agents.
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Extra resources for Analytical Determination of Nicotine and Related Compounds and their Metabolites
Sample text
Due to such selections, it may be that the dramatic rises of alkaloid contents observed in 'wild' Nicotiana spp. consequent upon folivory have been diminished or even eliminated from commercially developed lines of N. tabacum. Root versus shoot as the site of nicotine biosynthesis Why does the tobacco plant produce nicotine in the root and then translocate it to the shoot? Why, instead, is nicotine not produced in the aerial part of the plant, where it acts in defense against folivory? Karban and Baldwin [108] provide a simple and persuasive rationale for this apparent paradox.
1973: 37; 1755-1757. 79 Tiburcio AF, Kaur-Sawhney R, Ingersoll RB, Galston AW. Correlation between polyamines and pyrrolidine alkaloids in developing tobacco callus. , 1985: 78; 323-326. 80 Hashimoto T, Yamada Y. Regulation of tobacco alkaloid biosynthesis. ), Current Topics Plant Physiol 1995: 15; 130-144. 81 Baldwin IT. Chemical changes rapidly induced by folivory. ), Boca Raton: CRC Press, 1994: 5; 1-23. 82 Karban R, Baldwin IT. Induced Responses to Herbivory. Chicago: Univ. Chicago Press, 1997.
Rustica. The alkaloid contents of cultures were measured at suitable times, and compared with the alkaloids of untransformed plants of the same species. The number of integrations of T-DNA did not proportionately affect alkaloid contents. Hairy root cultures of all seven transformed species contained significantly greater amounts (fresh weight basis) of nicotine, nornicotine, anatabine and anabasine than did roots of untransformed plants, grown aseptically on agar or in soil. The spectra of alkaloids were similar to those described by Saitoh et al.