Analytical toxicology for clinical, forensic, and by Robert A. Maes, Hans Brandenberger

By Robert A. Maes, Hans Brandenberger

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The initial enthusiasm based on the ability to monitor many drugs/metabolites has been tempered by the finding that basic pharmacokinetic principles fundamental to TDM are often ignored. Many investigators, however, have shown convincingly that a well-organized TDM consultative service can lead to improved patient care in a cost-effective and efficient manner. The future of TDM will involve broadening the scope of more traditional applications. Examples include using analysis of a drug-metabolite pair as a measure of liver function in patients with cirrhosis (102) or in liver transplantation (103).

1982) Simultaneous determination of amitriptyline, nortriptyline and their respective isomeric 10-hydroxy metabolites in plasma by liquid chromatography. J. Chromatogr. 230, 391 -400. 24. , Gray, S. & Jatlow, P. (1982) Steady state plasma concentrations of cis- and trans-10-OH amitriptyline metabolities. Clin. Pharmacol. Ther. 31, 609-616. 25. Fräser, A. D. & Isner, A. F. (1988) Optimal drug monitoring of carbamazepine by routine analysis of carbamazepine and carbamazepine 10,11-epoxide. Clin.

1981) Phenytoin monotherapy for epilepsy: a long term prospective study, assisted by serum level monitoring, in previously untreated patients. Epilepsia 22, 475-488. 36. Cobos, J. E.

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