Basic & Clinical Pharmacology, Ninth Edition by Bertram G. Katzung

By Bertram G. Katzung

The most modern, authoritative, and accomplished pharmacology e-book for clinical, pharmacy, and different well-being technology scholars. commonly revered for its readability, comprehensiveness, and association, this pharmacology direction booklet provides the basic recommendations that scholars want to know in regards to the technological know-how of pharmacology and their software. makes a speciality of the elemental ideas of every drug staff in addition to the scientific selection and use of substances in sufferers and the tracking in their results.

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Extra resources for Basic & Clinical Pharmacology, Ninth Edition

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5 L/kg. Clearance Drug clearance principles are similar to the clearance concepts of renal physiology. Clearance of a drug is the factor that predicts the rate of elimination in relation to the drug concentration: Clearance, like volume of distribution, may be defined with respect to blood (CLb), plasma (CLp), or unbound in water (CLu), depending on the concentration measured. It is important to note the additive character of clearance. Elimination of drug from the body may involve processes occurring in the kidney, the lung, the liver, and other organs.

Drugs with very high volumes of distribution have much higher concentrations in extravascular tissue than in the vascular compartment, ie, they are not homogeneously distributed. 8 L/70 kg (Table 3–2) for a drug that is restricted to the plasma compartment. Table 3–2. Physical Volumes (in L/Kg Body Weight) of Some Body Compartments into Which Drugs May Be Distributed. 6 L/kg1) Small water-soluble molecules: eg, ethanol. 2 L/kg) Larger water-soluble molecules: eg, gentamicin. 04 Strongly plasma protein-bound molecules and very large L/kg) molecules: eg, heparin.

Thus, studies of the relation between structure and activity of a series of agonists and antagonists can identify a species of receptor that mediates a set of pharmacologic responses. Exactly the same experimental procedure can show that observed effects of a drug are mediated by different receptors. In this case, effects mediated by different receptors may exhibit different orders of potency among agonists and different KI values for each competitive antagonist. Wherever we look, evolution has created many different receptors that function to mediate responses to any individual chemical signal.

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