By Trevor J. Franklin, George Alan Snow
The topic is one in all significant curiosity in easy microbiology and infectious ailments and the booklet is a identified vintage.
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Extra resources for Biochemistry and Molecular Biology of Antimicrobial Drug Action
Example text
Am. Chem. Soc. B. M. (1997). Lipopeptide inhibitors of fungal glucan synthase. J. Med. Vet. Mycol, 35, 79. , Harley, ],P. A. (1996). Microbiology, Wm. C. Brown, Dubuque IA. M. (1996). Crystal structure of vancomycin. Structure 4, 1509-15. Skarzynski, T. et al. (1996). Structure of UDP-N-acetyl glucosamine enol pyruvyl transferase: an enzyme essential for the synthesis of bacterial peptidoglycan, complexed with substrate UDP-N-acetyl glucosamine and the drug fosfomycin. Structure 4, 1465-74. 1 Microbe killers: antiseptics and disinfectants The major interest throughout this book lies in the mechanism of action of drugs that can be used against microbial infections.
45, 3767, Ghuysen, ],-M, et al. (1996). Penicillin and beyond: evolution, protein fold, multimodular polypeptides and multi protein complexes. Microb. Drug Resist. 2, 163-75. E. (1997), The bacterial outer membrane as a drug permeability barrier. Trends Microbial. 5, 3742. Johnsson, K. G. (1994). Mechanistic studies of the oxidation of isoniazid by the catalase-peroxidase from Mycobacterium tuberculosis. J. Am. Chem. Soc. B. M. (1997). Lipopeptide inhibitors of fungal glucan synthase. J. Med. Vet.
The biosynthesis of the pentapeptide is completed by addition not of an amino acid but of a dipeptide, o-alanyl-o-alanine, which is separately synthesized. A racemase acting on L-alanine gives o-alanine, and a ligase then joins two molecules, giving the dipeptide. The completed UDP-N-acetylmuramyl intermediate (V) with its pendant peptide group will be referred to as the 'nucleotide pentapeptide'. 4 acid. 20 Peptidoglycan synthesis in Staphylococcus aureus. 5 Peptidoglycan synthesis. Stage 2: formation of UDP-N-acetylmuramyl pentapeptide.