By Joachim W. Fluhr, Peter Elsner, Enzo Berardesca, Howard I. Maibach
Bioengineering of the surface, or extra exactly the biophysical overview of dermis body structure, is relocating quickly from a descriptive method of a deeper knowing of biophysical and biochemical tactics. This moment variation of the preferred textual content Bioengineering of the outside: Water and Stratum Corneum displays the growth within the box, concentrating on the dramatically enhanced knowing of pores and skin body structure. particularly, it experiences the shift in our figuring out of the stratum corneum from an inert surrounding sheet to a biologically lively compartment.
The stratum corneum is the interface among the occasionally harsh setting and the inner turmoil of the human physique. in keeping with a good number of fresh courses, this ebook explains the mechanisms taken with stratum corneum barrier functionality and hydration. It displays 10 years of development not just of the non-invasive biophysical overview of pores and skin body structure parameter, but additionally of the perfection of the on hand units. It brings all study on epidermal water and transepidermal water loss in well-being and ailment updated with the revision of current chapters in addition to additional chapters from new members on hydration and itching. This version additionally comprises new directions at the standardization of measurements.
Bioengineering of the outside will increase conversation in the study neighborhood and should be priceless for scientists within the epidermis bioengineering box by means of providing equipment that supply trustworthy and reproducible techniques for product checking out within the pharmaceutical and beauty industries, in addition to for simple learn
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Extra resources for Bioengineering of the Skin: Water and the Stratum Corneum, 2nd Edition
35. Maddens, S. et al. Kit signaling inhibits the sphingomyelin-ceramide pathway through PLC gamma 1: implication in stem cell factor radioprotective effect, Blood, 100, 1294, 2002. 36. E. , A new 6-hydroxy-4-sphingenine-containing ceramide in human skin, J. , 40, 1434, 1999. 37. Ponec, M. et al. New acylceramide in native and reconstructed epidermis, J. Invest. , 120, 581, 2003. 38. C. et al. Presence of intact intercellular lamellae in the upper layers of the stratum corneum, J. Invest. , 88, 714, 1987.
5 kJ/mol . Similarly, a thermal current peak (a dielectric polarization phenomenon) appears at 130°K, corresponding to a characteristic of the free-water fraction . It thus appears that above a water content value of about 19%, water molecules in hair condense in aggregates that retain the same polarization properties as in the liquid state, but lose the rotational properties of free water, as indicated by magnetic resonance spectroscopy experiments. As a result, the term “free water” is totally inappropriate; “intermediate water” would be more suitable.
Invest. , 111, 189, 1998. 51. W. et al. The composition and morphology of epidermal cyst lipids, J. Invest. , 89, 419, 1987. 52. , Role of stratum corneum lipid fluidity in transdermal drug flux, J. Pharm. , 76, 25, 1987. 53. A. , Functions of lipid rafts in biological membranes, Annu. Rev. Cell Dev. , 14, 111, 1998. 54. Johnson, M. , Phase behavior and aggregate structure in mixtures of dioleoylphosphatidylethanolamine and poly(ethylene glycol)-lipids, Biophys. , 80, 313, 2001. 55. L. , Modulation of membrane fusion by asymmetric transbilayer distribution of amino lipids, Biochemistry, 33, 12573, 1994.