By Curtis Klaassen
The main relied on all-in-one evaluate of the biomedical and environmental points of toxicology--NOW extra whole, updated, and in complete color
The worlds major and so much authoritative textbook on poisons has extra to supply students,toxicologists, and pharmacologists than ever sooner than. Now in complete colour, and carefully revised, the 8th version of Casarett & Doulls TOXICOLOGY: the elemental technological know-how of toxins not just promises a entire evaluation of the fundamental elements of toxicology, it bargains the main updated, revealing, and in-depth examine the systemic responses of poisonous substance on hand anywhere.
Combined with the most recent pondering through the fields best students plus stable assurance of basic rules, modes of motion, and chemical-specific toxicity, this landmark textual content maintains to set the normal for toxicology references.
NEW to the 8th Edition
- FULL-COLOR layout to permit for a clearer interpretation of the elemental elements of toxicology featured during the text
- increased tables, illustrations, and different visuals are up to date with cutting-edge criteria that makes this version much more present and relevant
- NEW CHAPTERS contain «Toxic results of energy» and «Toxic results of Nanoparticles»
Read Online or Download Casarett & Doull's Toxicology The Basic Science of Poisons, Eighth Edition PDF
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Additional resources for Casarett & Doull's Toxicology The Basic Science of Poisons, Eighth Edition
Specificity of association (cause is tightly linked to an outcome) Although the guidelines provided by Hill were originally designed for interpretation of epidemiological data, they are equally applicable to establishing causation in toxicology, which often relies on a mix of both epidemiological and toxicological data. Quantitative risk assessment was developed in part to address issues of uncertainty related to potential harm. The risk assessment process summarizes data for risk managers and other decision makers, who must take into consideration to some degree the qualitative elements of ethical, social, and political issues.
Whereas risk management clearly has an ethical and values-based aspect, risk assessment is not immune from the influence of one’s values, bias, or perspective. Ultimately action is required and as Hill (1965) noted: “All scientific work is incomplete—whether it be observational or experimental. All scientific work is liable to be upset or modified by advancing knowledge. ” These so-called Bradford Hill criteria were developed largely as a “weight-of-evidence” approach for interpreting a body of epidemiology data, yet are relevant as well to toxicology.
DOSE–RESPONSE RELATIONSHIP GENERAL PRINCIPLES OF TOXICOLOGY The characteristics of exposure and the spectrum of toxic effects come together in a correlative relationship customarily referred to as the dose–response relationship. Whatever response is selected for measurement, the relationship between the degree of response of the biological system and the amount of toxicant administered assumes a form that occurs so consistently as to be considered the most fundamental and pervasive concept in toxicology.