Drug-Drug Interactions, Second Edition (Drugs and the by A. David Rodrigues

By A. David Rodrigues

Authored via well known leaders within the box, this accomplished quantity covers all features of drug-drug interactions, together with preclinical, scientific, toxicological, and regulatory views. completely up-to-date, this moment variation displays the numerous advances and contains huge new fabric on: key interaction among transporters and enzymes in drug metabolism and drug interactions the essential function of pharmacogenetics in metabolism-based drug-drug interactions in vivo – in vitro correlations (reversible, mechanism-based inhibition, induction) in silico methods permitting structure-activity and structure-function reviews high-throughput screening and GLP tools for comparing drug interactions in vitro using transgenic animal types to guage drug interactions delivering valuable case examples and computer-aided modeling, Drug-Drug Interactions is full of over two hundred priceless tables, equations, and figures to explain key suggestions, and accommodates severe new up to date info.

Show description

Read or Download Drug-Drug Interactions, Second Edition (Drugs and the Pharmaceutical Sciences) PDF

Best toxicology books

Handbook of Pesticide Toxicology, Volumes 1-2 (3rd Edition)

The instruction manual of Pesticide Toxicology is a complete, two-volume reference advisor to the homes, results, and rules of insecticides that offers the newest and so much entire info to researchers investigating the environmental, agricultural, veterinary, and human-health affects of pesticide use. Written by way of overseas specialists from academia, govt, and the non-public area, the instruction manual of Pesticide Toxicology is an in-depth exam of serious concerns relating to the necessity for, use of, and nature of chemical compounds utilized in sleek pest administration. This up to date 3rd variation contains at the book's culture of serving because the definitive reference on pesticide toxicology and recognizies the seminal contribution of Wayland J. Hayes, Jr. , co-Editor of the 1st edition.

Feature: offers a complete examine all facets of pesticide toxicology in a single reference paintings.
Benefit: Saves researchers time in quick gaining access to the very most recent definitive info on toxicity of particular insecticides instead of looking through millions of magazine articles.

Feature: transparent exposition of possibility id and dose reaction relationships in each one bankruptcy that includes pesticide brokers and actions
Benefit: Connects the experimental laboratory effects to real-life functions in human well-being, animal future health and the environment.

Feature: All significant periods of pesticide considered.
Benefit: presents relevance to a much broader number of researchers who're engaging in comparative paintings in insecticides or their wellbeing and fitness impacts.

Feature: diversified routes of publicity severely evaluated.
Benefit: Connects the loop among publicity and damaging impacts to people who are discovering the impacts of insecticides on people or wildlife.

Chemical Evolution: The Biological System of the Elements

This e-book is written for researchers and scholars drawn to the functionality and position of chemical components in organic or environmental platforms. specialists have lengthy identified that the Periodic procedure of components (PSE) offers merely an insufficient chemical description of parts of organic, environmental or medicinal significance.

Animal Clinical Chemistry - A Practical Handbook for Toxicologists and Biomedical Researchers

10+ Years of Updates considering First version newbies to the animal medical chemistry and toxicology fields speedy locate that a similar principles of human drugs don't consistently practice. Following within the footsteps of its standard-setting first version, Animal scientific Chemistry: a realistic guide for Toxicologists and Biomedical Researchers, moment version collates details largely dispersed in journals and publication chapters, concentrating on the main proper literature to experimental toxicology and its contrast from human drugs.

Environmental Toxicology Assessment

Size of the level of the poisonous insult because of the substance concerned is of significance whilst venture an environmental toxicology evaluate. this article outlines a number of the dimension suggestions which have been lately constructed and

Additional resources for Drug-Drug Interactions, Second Edition (Drugs and the Pharmaceutical Sciences)

Example text

Then, CL (strictly based on measurements in whole blood to conserve mass balance) is equal to, and cannot exceed, organ blood flow; clearance is then limited by, and is sensitive to, changes in perfusion rate. 3d] [17/12/07/12:9:37] [1–30] 8 Rowland Figure 5 Schematic of the extraction of a drug by an eliminating organ at steady state, illustrating the interrelationships between blood clearance, extraction ratio, and organ blood flow. See the text for appropriate equations. Source: From Ref. 1.

Theoretical considerations of the well-stirred and parallel-tube model. Influence of hepatic blood flow, plasma and blood cell binding, and hepatocellular enzymatic activity on hepatic drug clearance. J Pharmacokinet Biopharm 1977; 5:625–653. 12. Roberts MS, Donaldson JD, Rowland M. Models of hepatic elimination: a comparison of stochastic models to describe residence time distributions and to predict the influence of drug distribution, enzyme heterogeneity, and systemic recycling on hepatic elimination.

Kinetics of drug-drug interactions. J Pharmacokinet Biopharm 1973; 1:553–567. 5. Shaw PN, Houston JB. Kinetics of drug metabolism inhibition: use of metabolite concentration-time profiles. J Pharmacokinet Biopharm 1987; 15:497–510. 6. O’Reilly RA. Interaction of sodium warfarin and rifampin. Ann Int Med 1974; 81:337–340. 7. Alvan G, Piafsky K, Lind M, et al. Effect of pentobarbital on the disposition of alprenolol. Clin Pharmacol Ther 1977; 22:316–321. 8. Tozer TN. Concepts basic to pharmacokinetics.

Download PDF sample

Rated 4.19 of 5 – based on 34 votes