By A. David Rodrigues
Authored via well known leaders within the box, this accomplished quantity covers all features of drug-drug interactions, together with preclinical, scientific, toxicological, and regulatory views. completely up-to-date, this moment variation displays the numerous advances and contains huge new fabric on: key interaction among transporters and enzymes in drug metabolism and drug interactions the essential function of pharmacogenetics in metabolism-based drug-drug interactions in vivo – in vitro correlations (reversible, mechanism-based inhibition, induction) in silico methods permitting structure-activity and structure-function reviews high-throughput screening and GLP tools for comparing drug interactions in vitro using transgenic animal types to guage drug interactions delivering valuable case examples and computer-aided modeling, Drug-Drug Interactions is full of over two hundred priceless tables, equations, and figures to explain key suggestions, and accommodates severe new up to date info.
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Additional resources for Drug-Drug Interactions, Second Edition (Drugs and the Pharmaceutical Sciences)
Example text
Then, CL (strictly based on measurements in whole blood to conserve mass balance) is equal to, and cannot exceed, organ blood flow; clearance is then limited by, and is sensitive to, changes in perfusion rate. 3d] [17/12/07/12:9:37] [1–30] 8 Rowland Figure 5 Schematic of the extraction of a drug by an eliminating organ at steady state, illustrating the interrelationships between blood clearance, extraction ratio, and organ blood flow. See the text for appropriate equations. Source: From Ref. 1.
Theoretical considerations of the well-stirred and parallel-tube model. Influence of hepatic blood flow, plasma and blood cell binding, and hepatocellular enzymatic activity on hepatic drug clearance. J Pharmacokinet Biopharm 1977; 5:625–653. 12. Roberts MS, Donaldson JD, Rowland M. Models of hepatic elimination: a comparison of stochastic models to describe residence time distributions and to predict the influence of drug distribution, enzyme heterogeneity, and systemic recycling on hepatic elimination.
Kinetics of drug-drug interactions. J Pharmacokinet Biopharm 1973; 1:553–567. 5. Shaw PN, Houston JB. Kinetics of drug metabolism inhibition: use of metabolite concentration-time profiles. J Pharmacokinet Biopharm 1987; 15:497–510. 6. O’Reilly RA. Interaction of sodium warfarin and rifampin. Ann Int Med 1974; 81:337–340. 7. Alvan G, Piafsky K, Lind M, et al. Effect of pentobarbital on the disposition of alprenolol. Clin Pharmacol Ther 1977; 22:316–321. 8. Tozer TN. Concepts basic to pharmacokinetics.