Genomics in Regulatory Ecotoxicology: Applications and by Gerald Ankley, Ann Miracle, Edward J. Perkins, George P.

By Gerald Ankley, Ann Miracle, Edward J. Perkins, George P. Daston

Fueled partly by means of huge, well-publicized efforts reminiscent of the Human Genome venture, genomic examine is a speedily transforming into zone in a number of organic disciplines, together with toxicology. a lot of this strength, in spite of the fact that, has been mentioned within the literature and at technical conferences basically in fairly huge phrases, making it tough to evaluate precisely how info generated from new genomics applied sciences may truly influence or profit the danger overview approach.

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Additional resources for Genomics in Regulatory Ecotoxicology: Applications and Challenges

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Amin et al. 2002; Hamadeh et al. 2002). Microarray research with mammalian models has been far more prevalent than in species used in regulatory ecotoxicology. , Larkin et al. 2003; Miracle et al. 2003; Rasooly et al. 2003; Williams et al. 2003; Kimura et al. 2004; Snape et al. 2004; Tilton et al. 2005; van der Ven et al. 2005; von Schalburg et al. 2005; Lettieri 2006). Transcription of mRNA is only an intermediate step in conversion of genetic information into proteins, the biochemical basis of biological function.

Considering the multitude of chemicals and situations that need to be considered for ecological testing, it seems logical that genomic technologies could play a role in screening and prioritizing within a regulatory ERA framework. From a prospective ERA stance, the registration of new chemicals can sometimes be best described as a “shot in the dark”. Except for pharmaceuticals and pesticides where the MOA is usually known in vertebrates, there are no or limited background data for most chemicals in commerce that can help guide testing.

Niehs. htm). Acceptance of genomic-based assays will require collaborative efforts by research and regulatory scientists, and ongoing collaborative research is currently providing focus and information for national and international validation efforts. indb 14 10/26/07 4:53:24 PM Application of Genomics to Screening 15 The purpose of this chapter is to describe some of the current and planned applications of genomic technologies to screening assays for use in ecotoxicology decision making, including risk assessment.

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