Handbook of Toxicologic Pathology by Wanda M. Haschek

By Wanda M. Haschek

This can be the 1st accomplished reference paintings on toxicologic pathology, an rising box that integrates the mechanisms of poisonous damage with the ensuing pathology. Chapters deal systematically with organ-specific poisonous damage, describing the mechanisms of harm, morphological expression of the harm, and assessment of the pathology. extra chapters introduce the sphere to the uninitiated and tackle such issues as concepts used for morphological review, chance evaluation, and regulatory facets. The Handbook of Toxicologic Pathology will speedy determine itself because the vintage reference paintings during this box for future years.

Key Features
* finished, ''user friendly'' reference textual content on toxicologic pathology
* huge, easy-to-use eight 1/2'' x 11'', double-column format
* Systematic method of every one organ or system
* greater than 500 illustrations and ninety tables supplement the text
* Over 2,000 references for simple entry to the first literature
* detailed chapters written via best professionals

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Additional resources for Handbook of Toxicologic Pathology

Sample text

Section thickness distorts the edge of the tissue, thereby affecting measurements. For example, an angular structure has a short leading and a long trailing edge when sectioned. The thicker the section, the longer the trailing edge, hence different data will be generated depending on the thickness of the section. This phenomenon whole cell (P t), that is, V v = P-JPV The surface density (5 V) of a structure can be determined if the total length of the grid line is known and the number of times the line intercepts the structure in question is known (/L), that is, S v = 2/L.

Most morphometric measurements in toxicology entail either counting specific elements such as nuclei; planimetry, which entails measurement of the surface area; or point counting using a grid or 38 overlay to determine areas or volumes. Counting cell elements, for example, a differential white blood cell count on a stained blood smear, is prob­ ably the oldest form of microscopically quantify­ ing tissues. Accuracy of the data generated from counting cell elements in a tissue section is depen­ dent on shape and size of the elements.

Currently available techniques in pathology cannot restore autolysed tissues; hence, autolysis equates with wasted investment, since the morphologic endpoints often cannot be deter­ mined. Standard operating procedures should mandate two or more inspections of the animal colony each day for moribund or dead animals; they should be removed for immediate necropsy. Bodies should be refrigerated if prompt necropsy is not possible, but for no longer than 8 hrs for small rodents. Histologic postmortem changes in the rat have been recently described (Seaman, 1987).

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