Handbook of toxicology by Michael J Derelanko; Mannfred A Hollinger (eds.)

By Michael J Derelanko; Mannfred A Hollinger (eds.)

Laboratory animal administration / Joseph C. Siglin and William H. Baker -- Acute, subchronic, and protracted toxicology / Carol S. Auletta -- Dermal inflammation and sensitization / Kimberly L. Bonnette, sunrise D. Rodabaugh and Christopher W. Wilson -- Ocular toxicology / Brendan J. Dunn -- basic inhalation toxicology / Paul E. Newton -- utilized inhalation toxicology / Gary M. Hoffman -- primary neurotoxicology / Gene E. Schulze -- utilized neurotoxicology / Rosemary C. Mandella -- Immunotoxicology : basics of preclinical evaluation / Robert V. condo and Peter T. Thomas -- Renal toxicology : renal functionality parameters for grownup Fischer-344, Sprague-Dawley, and Wistar rats / William J. Powers, Jr. -- Reproductive toxicology / Donald J. Ecobichon -- Developmental toxicology / Karen M. MacKenzie and Richard M. Hoar -- Endocrine toxicology : male copy / Suresh C. Sikka and Rajesh okay. Naz -- Endocrine toxicology : the feminine reproductive method / Patricia B. Hoyer and Patrick J. Devine -- Genetic toxicology / Richard H.C. San ... [et al.] -- Carcinogenesis / Michael J. Derelanko -- Animal histopathology / John C. Peckham -- Animal scientific pathology / Barry S. Levine -- Metabolism and toxicokinetics of xenobiotics / Mohamed B. Abou-Donia, Eman M. Elmasry and Aqel W. Abu-Qare -- In vitro equipment for the prediction of ocular and dermal toxicity / John W. Harbell and Rodger D. Curren -- Ecotoxicology / David J. Hoffman ... [et al.] -- steel toxicology / Akira Yasutake and Kimiko Hirayama -- Human medical toxicology / Jill Dolgin -- threat overview ; Regulatory toxicology within the usa : an outline / Michael J. Derelanko -- Regulatory toxicology : U.S. EPA/chemicals (TSCA) / Henry C. Fogle -- Regulatory toxicology : U.S. EPA/pesticides (FIFRA) / Jane E. Harris -- Regulatory toxicology : U.S. FDA/pharmaceuticals / William J. Powers, Jr. -- Regulatory toxicology : clinical units / Steven J. Hermansky -- Regulatory toxicology : shopper items / Dennis J. Naas -- Regulatory toxicology : notification of latest components within the ecu Union / Michael J. Derelanko -- Regulatory toxicology : notification of latest ingredients in Canada, Korea, Australia, and China / Henry C. Fogle -- Miscellaneous info of toxicological importance / Mannfred A. Hollinger and Michael J. Derelanko

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Ketamine hydrochloride (Vetalar)(Ketaset): (Changed to a Schedule III drug by the DEA in August, 1999): Dissociative anesthetic agent that produces a state of chemical restraint and anesthesia. Reflexes remain intact. Excessive salivation may be controlled with atropine. Ketamine hydrochloride has a wide margin of safety and relatively short duration and recovery time, with minimal adverse side effects. • Medetomidine hydrochloride (Domitor): A synthetic α2-adrenoreceptor agonist which produces sedation and analgesia for clinical and minor surgical procedures not requiring muscle relaxation.

11 Minimum Cage Space Requirements for Micea a Body Weight (g) Floor Area/Mouse (sq. 0 5 5 5 5 As per the Guide for the Care and Use of Laboratory Animals, 1996. Copyright © 2002 by Taylor & Francis 4. Environmental Conditions Environmental conditions recommended for mice by the Guide are as follows: Room temperature: 64–79°F, 18–26°C Relative humidity: 30–70% Room air changes: 10–15/hour Environmental controls should be set toward the middle of the room temperature and relative humidity ranges to avoid extremes and large fluctuations in these environmental variables.

The chamber must be well lit and have viewing ports that allow observation of the animals. • The CO flow rate must be adequate to rapidly achieve a CO concentration of at least 6%. • If the CO chamber is inside, CO monitors must be placed in the room to warn personnel of hazardous CO concentrations. 4. Inert Gases Inert gases such as nitrogen and argon are colorless, odorless, nonflammable, and nonexplosive gases that have been used to induce euthanasia by hypoxemia. Although these gases are readily available and minimally hazardous to personnel, their use requires prior sedation or anesthesia of the animal to avoid discernible hypoxemia and ventilatory stimulation which commonly precede death and are obviously distressing.

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