By Harold I. Zeliger (Auth.)
"An easy-to-read publication that are supposed to be in any toxicologist's library. With an important attempt of synthesis, the writer has taken care of a large choice of matters within the rising box of chemical mixtures." -- Arturo Ortego, M.D., college of drugs and healthiness Sciences, Rovira I Virgili college, Reus, Spain
, Pages xxi-xxiii
1 - Introduction
, Pages 3-6
2 - health and wellbeing results of Exposures to Chemical Mixtures
, Pages 7-15
3 - Absorption of Chemical Mixtures
, Pages 17-22
4 - Chemical Toxicology
, Pages 23-49
5 - Scope and resources of poisonous Exposures
, Pages 53-57
6 - In Utero Exposure
, Pages 59-62
7 - Air Pollution
, Pages 63-77
8 - Water Pollution
, Pages 79-119
9 - Soil Pollution
, Pages 121-127
10 - Food
, Pages 129-156
11 - chemical substances in and round the Home
, Pages 157-174
12 - ailing development Syndrome
, Pages 175-195
13 - business Exposure
, Pages 197-211
14 - Pesticides
, Pages 213-228
15 - Alcohol and Tobacco: leisure Toxins
, Pages 229-244
16 - Electromagnetic Radiation and poisonous Exposure
, Pages 245-258
17 - breathing System
, Pages 261-293
18 - worried System
, Pages 295-326
19 - Developmental Neurotoxicology
, Pages 327-333
20 - Autism: impact of Maternal publicity to Neurotoxic Chemicals
, Pages 335-349
21 - cognizance Deficit Hyperactivity illness (ADHD)
, Pages 351-359
22 - Endocrine System
, Pages 361-380
23 - poisonous Infertility
, Pages 381-400
24 - Teratogens
, Pages 401-415
25 - Immune System
, Pages 417-427
26 - Chemical Sensitivity: a number of Chemical Sensitivity (MCS), power Fatigue Syndrome (CFS), Fibromyalgia (FM), and Gulf conflict Syndrome (GWS)
, Pages 429-457
27 - Skin
, Pages 459-472
28 - Musculoskeletal System
, Pages 473-480
29 - Cardiovascular System
, Pages 481-493
30 - Liver
, Pages 495-506
31 - Kidneys
, Pages 507-513
32 - Cancer
, Pages 515-551
33 - formative years Cancer
, Pages 553-557
34 - melanoma Clusters
, Pages 559-570
35 - Regulatory Requirements
, Pages 573-581
36 - Conclusions and Recommendations
, Pages 583-588
, Pages 589-592
, Pages 593-600
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Extra info for Human Toxicology of Chemical Mixtures. Toxic consequences Beyond the impact of One-Component Product and Environmental Exposures
These and other mixture effects are examined more closely in subsequent chapters. This chapter has aimed to alert the reader to the fact that toxic exposure begins at conception and impacts the fetus throughout gestation and beyond. References 1. Environmental Working Group. 1 Introduction Air pollution is a primary source of exposure to a wide variety of toxic chemicals. The air we breathe contains numerous xenobiotics as well increased concentrations of naturally occurring chemicals such as ozone and particulate matter.
Though essentially water insoluble, they adhere to lipophilic solids and are carried in ocean currents. They are ultimately passed up the food chain by bioaccumulation. PBDEs, like PCBs and chlorinated pesticides before them, have reached the Arctic.  References 1. gov/triinter/chemcial/ 2. Roe D, Pease W, Florini K, Silbergeld E. Toxic ignorance: The continuing absence of basic health testing for top selling chemicals in the United States. Environmental Defence Fund, 1997. 3. Greater Boston Physicians for Social Responsibility.
Transport of hydrophiles to parts of the body they would not ordinarily reach by their solution in lipophiles. Transport of xenobiotics to unexpected parts of the body can result in body responses not found for single chemical absorption. indd 46 5/16/2008 1:08:02 PM 4: CHEMICAL TOXICOLOGY 47 reaching the lower airways.  3. The interaction of a toxic chemical with its metabolite or the metabolite of another species. Phase I metabolism of xenobiotics produces hydrophiles. These hydrophiles may dissolve in lipophiles and be transported in the body.