In Vitro Methods in Pharmaceutical Research by Jose V. Castell, Maria Jose Gmez-Lechn

By Jose V. Castell, Maria Jose Gmez-Lechn

In Vitro tools in Pharmaceutical learn presents a accomplished advisor to laboratory concepts for comparing in vitro organ toxicity utilizing mobile versions. step by step useful the right way to practice and interpret assays for drug metabolism and toxicity evaluate are supplied, in addition to a comparability of other strategies to be had. it's a great addition to the literature at a time while curiosity is becoming in mobile in vitro types for toxicology and pharmacology experiences. Key positive aspects* Meets the continued call for for info during this box* Compares In Vitro thoughts with different tools* Describes cell-culture equipment used to enquire toxicity in cells derived from diversified organs* comprises contributions through prime specialists within the box

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A. Finite cell lines . . . . . . . . . . . . . . . . . . . . . . B. C o n t i n u o u s cell lines . . . . . . . . . . . . . . . . . . . . C. Static and perfusion cell systems . . . . . . . . . . . . . . . . D. Criteria for identification and m o n i t o r i n g of g r o w t h . . . . . . . . . 1. K a r y o t y p i n g . . . . . . . . . . . . . . . . . . . . . 2. Aging in culture .

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29. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. 43. 44. 45. 46. 47. 48. QSAR and In Vitro Toxicology 31 approximation of the laws, regulations and administrative provisions relating to the classification, packaging and labelling of dangerous substances. Official Journal of the European Communities, L110A. ECETOC (1995) ECETOC Technical Report No. 66. Skin Irritation and Corrosion. Reference Chemicals Data Bank, European Centre for Ecotoxicology and Toxicology of Chemicals, Brussels. , Blaauboer, B.

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