Metallothioneins and Related Chelators (Volume 5) (Metal by Astrid Sigel, Roland K. O. Sigel

By Astrid Sigel, Roland K. O. Sigel

Those sulfur-rich chelators, being very important in steel ion homeostasis, locate expanding consciousness. MILS-5, written via 30 the world over famous specialists, makes a speciality of this sizzling subject. The reader is supported through approximately 20 tables, greater than eighty illustrations and approximately 2000 references. This ebook is an important source for scientists operating in quite a lot of disciplines from environmental toxicology and inorganic biochemistry throughout to body structure and medication.

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Additional info for Metallothioneins and Related Chelators (Volume 5) (Metal Ions in Life Sciences)

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NORDBERG with species. For humans and other primates it is on chromosome 16 [34]. The protein consists of a number of isoforms coded by various alleles. , Cd, Cu, and Zn. 4 times more MT-1 RNA than MT-2 RNA exists, indicating that the transcription rate is slightly higher for the MT-1 gene compared to the MT-2 gene [34]. MT-1A and MT-2A genes seem to be differentially regulated by metals. Lack of MT gene expression makes the organism sensitive to toxic effects. The MT gene becomes transcriptionally inactive as a consequence of DNA methylation.

In adenoid cystic carcinomas MT immunolocalization may be important [112]. 3. Metallothionein in the Treatment of Diseases Different MT synthesis in tumor tissue compared to normal tissue has been suggested as a basis for treatment. The possible use of cadmium as a cancer treatment agent in some forms of liver tumors was discussed [113] based on observations in mice. Animals that were treated with combinations of Cd and NDEA (N-nitrosodiethylamine) did not develop liver tumors in contrast to animals treated only with the tumorigenic agent NDEA.

This is likely to influence the results. In experimental studies [57] excretion of MT, cadmium, calcium, and various Met. Ions Life Sci. 2009, 5, 1–29 10 Table 3. M. NORDBERG and G. F. 01–1 ng/g 42 ng/g 1–10 ng/g 410 ng/g 1880 mg/g CR 880 mg/g CR 394 mg/g CR 120 and 210 mg/g CR 320 and 1050 mg/g CR a b [55] Collected from data published in [51,52]. Occupational exposure, abnormal denotes presence of low molecular weight proteinuria. enzyme markers in urine were followed in male rats exposed to cadmium.

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