By D. L. J. Opdyke
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Extra info for Monographs on Fragrance Raw Materials: A Collection of Monographs Originally Appearing in Food and Cosmetics Toxicology
The liquefaction of spontaneous tumors of the mammary gland in mice by heptyl aldehyde. Y. 87, 144. Strong, L. C. & Whitney, L. F. (1938). The treatment of spontaneous tumors in dogs by the injection of heptyl aldehyde. Y. 88, 111. Williams, R. T. (1959). Detoxication Mechanisms. The Metabolism and Detoxication of Drugs, Toxic Substances and Other Organic Compounds. , p. 92. , London. Yoshida. M.. , Matsui. M. & Oda. R. (1970). Availability of energy in alcohols, aldehydes and ketones by growing chicks.
Furia and N. Bellanca. p. 433. , Cleveland, O h i o . Flavoring Extract Manufacturers' Association (1965). Survey of flavoring ingredient usage levels. N o . 2567. Fd Technoi, Champaign 19 (2), part 2, 155. Food Chemicals Codex (1972). 2nd ed. Prepared by the Committee on Specifications, Food Chemicals Codex. of the C o m m i t t e e on F o o d Protection, p. 372. National Academy of Sciences-National Research Council Publ. C. Gerarde, H. W. & Ahlstrom, D o r o t h e a B. (1966). T h e aspiration hazard and toxicity of a homologous series of alcohols.
A maximum permissible concentration of 01 mg/litre has been suggested (Zaeva & Fedorova, 1963). Biological data Acute toxicity. The acute oral L D 5 () in mice was reported as 4 g/kg (Zaeva & Fedorova, 1963) and in rats as 4-87 g/kg (Bär & Griepentrog, 1967) and 4-59 g/kg (Smyth, Carpenter & Weil, 1951). The acute dermal L D 5 0 in rabbits was reported as 3-1 ml/kg (Smyth et al. 1951) and as > 5 g/kg (Moreno, 1974). The maximum period of survival of rats inhaling the saturated vapours of hexanol was reported as 8 hr (Smyth et al.