Ocular Toxicology by Ingo Weisse (auth.), Ingo Weisse, Otto Hockwin, Keith Green,

By Ingo Weisse (auth.), Ingo Weisse, Otto Hockwin, Keith Green, Ramesh C. Tripathi (eds.)

On behalf of the editorial board and the organizing committee of the 4th congress of the foreign Society of Ocular Toxicology (I SOT), held in AnnecyNeyrier du Lac, France, October nine -13, 1994, we're happy to offer to the ocular toxicology neighborhood this listed quantity of our congress complaints. The 4th congress was once designed basically to facilitate and replace the data in ocular electrophysiology and ocular pharmacokinetics, in either the scientific and preclinical facets. the end result of this 4th congress, verified during this quantity, is an invaluable contribution to the meth­ odology in either fields and should with a bit of luck help in the overview and interpretation of ocular findings recorded in animal reports on medicines and different chemical compounds, so that it will safeguard human future health. surely, paintings at the mechanisms of ocular toxicology within the technique of pharmaceutical improvement needs to proceed and those court cases, embodying the offered papers, will upload to the knowledge base. The editors, the congress organizing committee and the participants of the foreign Society of Ocular Toxicology thank the audio system who gave their time, wisdom, and services to help us during this venture. the subsequent manuscripts include the most substance of every of the platform shows and, often times, even more. additionally, our thank you visit the entire members coming from quite a number historical past- regulatory, educational and commercial -for their consciousness and perfect contributions in the course of the discussion.

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Extra resources for Ocular Toxicology

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It is particularly useful with the scleral shell since curvature does not fit perfectly to the whole cornea. We use regularly jet electrodes but we have experience with other types of electrodes as described now. Electrodes Corneal electrodes. The eye of carnivores (conversely to primates) allows the use of large corneal electrodes. Many types of contact lenses have been developed and the most widely used in veterinary medicine were, until recently, scleral shells with different types of electrodes (silver loop, silver button) with conducting solution between cornea and shell.

1994. A proximal retinal component in the primate photopic ERG a-wave. Invest. Ophthal. Vis. Sci. 35: 635-645. M. 1978. Corneal wick electrode for recording bright flash electroretinograms and early receptor potentials. Arch. Ophthal. 96: 899-900. H. 1986. Scotopic threshold response of proximal retina in cat. I. Neurophys. 56: 1049-1061. A. and Nino, C. 1988. Scotopic threshold response (STR) of the human electroretinogram. Inv. Ophthal. Vis. Sci. 29: 1608-1614. A. H. 1987. Proximal retinal contribution to the intraretinal 8-Hz pattern ERG of the cat.

Thus, the ERG component most sensitive to cefazolin and ceftazidime is the oscillatory potentials. If we had examined only the classical a- and b-waves, the non-toxic dose of these B-lactams would have been over-estimated. lV 20msec Figure 3. Effects of an intravitreal injection of 500 }

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