By Stanley Feldman Dr, Professor of Accident and Emergency Medicine John A Henry, Senior Lecturer in Anaesthesia Lakshman Karalliedde
Few chemicals created by means of guy have triggered better controversy than organophosphates. Conceived as pesticides, they've got additionally been built to develop into the main feared of chemical guns. The keep an eye on of vectors of ailments from which thousands die or are disabled is seriously depending on organophosphates, as are efforts to take care of foodstuff creation within the face of out of control inhabitants progress, diminishing arable land and the potential of worldwide warming. because the toxicity of organophosphates is non-specific, it has brought on in poor health healthiness and demise in guy, and has contributed to opposed ecological results.
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Extra resources for Organophosphates and Health
Example text
Improvement with anticholinergic and antiglutaminergic therapeutics. R. Guillain-Barre syndrome following organophosphate poisoning. Journal of the American Medical Association 1977;238:1950-1. J. Organic Phosphorus Pesticides. In: Handbook of Pesticide Toxicology. R. eds. :Academic Press; San Diego 1991. p. 917-1123. B. T. eds. Saddle River, New Jersey: Prentice Hall International Ltd; 1991. p. , Elderfrawi, T. Action of organophosphates on GABAa receptor and voltage-dependent chloride channels.
Et al. Memory impairment after soman intoxication in the rat: correlation with central neuropathology. Improvement with anticholinergic and antiglutaminergic therapeutics. R. Guillain-Barre syndrome following organophosphate poisoning. Journal of the American Medical Association 1977;238:1950-1. J. Organic Phosphorus Pesticides. In: Handbook of Pesticide Toxicology. R. eds. :Academic Press; San Diego 1991. p. 917-1123. B. T. eds. Saddle River, New Jersey: Prentice Hall International Ltd; 1991. p.
G. Gray and Dawson, 1987). It should be noted that some OPs have a chiral structure and enantiomers exist that may have a major difference in antiChE activity. 5. 5. Ageing The development of enzyme reactivators for the treatment of OP poisoning revealed that these substances were ineffective in the case of poisoning with soman unless given very soon after exposure. The reason for this is that the complex that soman forms with AChE rapidly loses its bulky pinacolyl group to leave a monoalkyl phosphonylated complex.