By Jones D.G. (ed.)
The e-book includes 20 chapters and it should no longer be a long way unsuitable to assert that now not a unmarried one that has made a contribution to PBO is absent from the record of participants. except things like the houses, makes use of, plant metabolism, mammalian and environmental toxicology, and mode of motion of PBO, additionally coated are such expert matters because the dimension of synergism within the laboratory, and the capability use of PBO by myself to manage whiteflies and its use with insect progress regulators. moreover, molecular modelling makes an attempt to give an explanation for its worth in formulations.
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Additional resources for Piperonyl Butoxide
B) Rats A developmental toxicity study with PBO was performed in Sprague-Dawley rats by Chun and Neeper-Bradley (1991). Timed pregnant rats were administered PBO by gavage on gestation days 6 to 15. The dosage groups incorporated were 0, 200, 500 and 1000 mg kg-lday-land 25 animals were included in each group. In this study, the pregnancy rate was equivalent among groups and ranged from 88% to 96%. No females aborted, delivered early or were removed from the study. Gestational body weight and body weight gains were reduced in the 500 and 1000 mg kg -1 groups, as was food intake for the first 7 days.
They are considered an end-stage lesion and not part of a continuing neoplastic process. e. failure to grow in semi-solid agar, failure to transplant efficiently into nude mice, as well as their lack of activated oncogenes, distinguish them from the spontaneous adenomas or carcinomas otherwise seen in murine livers. The review by Buffer (1996) of the hepatic tumours related to MFO induction in the mouse supports these views. A 1-year hepatic carcinogenicity study was performed in male CD-1 mice by Takahashi et al.
The extensive toxicity data generated and its widespread use and long-term good standing lend considerable weight to this argument. The huge safety margins in a battery of toxicity tests, by a variety of routes, allow for considerable confidence in its use. The lack of toxicity of this compound in humans suggests that it poses little or no risk. W. (1968). Inhibition of microsomal drug metabolism by methylenedioxybenzenes. Biochem. Pharmocol. 17, 2367-2370. E. G. (1994). Use of precision-cut liver slices for studies of unscheduled DNA synthesis.