Pre-Test Pharmacology by Arnold Stern

By Arnold Stern

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Then, CL (strictly based on measurements in whole blood to conserve mass balance) is equal to, and cannot exceed, organ blood flow; clearance is then limited by, and is sensitive to, changes in perfusion rate. 3d] [17/12/07/12:9:37] [1–30] 8 Rowland Figure 5 Schematic of the extraction of a drug by an eliminating organ at steady state, illustrating the interrelationships between blood clearance, extraction ratio, and organ blood flow. See the text for appropriate equations. Source: From Ref. 1.

Theoretical considerations of the well-stirred and parallel-tube model. Influence of hepatic blood flow, plasma and blood cell binding, and hepatocellular enzymatic activity on hepatic drug clearance. J Pharmacokinet Biopharm 1977; 5:625–653. 12. Roberts MS, Donaldson JD, Rowland M. Models of hepatic elimination: a comparison of stochastic models to describe residence time distributions and to predict the influence of drug distribution, enzyme heterogeneity, and systemic recycling on hepatic elimination.

Kinetics of drug-drug interactions. J Pharmacokinet Biopharm 1973; 1:553–567. 5. Shaw PN, Houston JB. Kinetics of drug metabolism inhibition: use of metabolite concentration-time profiles. J Pharmacokinet Biopharm 1987; 15:497–510. 6. O’Reilly RA. Interaction of sodium warfarin and rifampin. Ann Int Med 1974; 81:337–340. 7. Alvan G, Piafsky K, Lind M, et al. Effect of pentobarbital on the disposition of alprenolol. Clin Pharmacol Ther 1977; 22:316–321. 8. Tozer TN. Concepts basic to pharmacokinetics.

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