By Ramesh C. Gupta
Reproductive toxicology is a fancy topic facing 3 components-parent, placenta, and fetus-and the continual adjustments that happen in each one. Reproductive and Developmental Toxicology is a accomplished and authoritative source delivering the most recent literature enriched with appropriate references describing each point of this zone of technology. It addresses a extensive variety of subject matters together with nanoparticles and radiation, gases and solvents, smoking, alcohol and medication of abuse, meals ingredients, nutraceuticals and prescription drugs, and metals, between others. With a unique concentrate on placental toxicity, this ebook is the single on hand connection with attach the 3 key possibility phases, and is the one source to incorporate reproductive and developmental toxicity in household animals, fish, and natural world. * offers a whole, built-in resource of data at the key hazard levels in the course of replica and improvement * comprises insurance of rising technology comparable to stem mobilephone software, toxicoproteomics, metabolomics, phthalates, infertility, teratogenicity, endocrine disruption, surveillance and regulatory issues, and possibility overview * bargains diversified and specified in vitro and in vivo toxicity versions for reproductive and developmental toxicity trying out in a straightforward layout that assists in comparative research
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Extra info for Reproductive and Developmental Toxicology
Example text
Epididymal and accessory sex gland function Epididymal development and function are dependent on the proper balance of androgenic and estrogenic stimulation and are required for normal male reproductive function and fertility. The accessory sex glands are considered to be primarily androgen dependent, and the secretions of these glands, as well as those of the epididymidis, are important components of seminal fluid. Conversion of testosterone to DHT can generally occur in the epididymidis, prostate and seminal vesicles.
7╇ The anatomical relationships between the accessory sex glands in sexually mature men and the histological appearance of the human prostate gland are shown. Figure was obtained, with permission, from Netter (1997). into spermatozoa which will eventually be released into the excurrent duct system. Each of these phases involves a different type of germ cell undergoing a different developmental process, and, as such, these phases have the potential to differ in their susceptibility to the mechanisms of action of various reproductive toxicants (Evans, 2007; Foster and Gray, 2008).
Estrogens are required for various aspects of the normal development and function of Sertoli cells and germ cells within the seminiferous tubules. Xenobiotics which mimic or inhibit the actions of estradiol within the testis can disrupt normal spermatogenesis. 3). , 2010). , 2010; Senger, 2007). , 2001). Antiandrogens and a variety of other xenobiotics can interfere with this feedback loop, resulting in excessive secretion of LH and Leydig or interstitial cell hyperplasia (Evans, 2007; Foster and Gray, 2008).