Safety Evaluation of Certain Food Additives: Sixty-eighth by WHO


This quantity includes monographs ready on the sixty-eighth assembly of the Joint FAO/WHO professional Committee on meals ingredients (JECFA), which met in Geneva Switzerland from 19 to twenty-eight June 2007. The toxicological monographs during this quantity summarize the security info on a couple of nutrition ingredients: acidified sodium chlorite asparaginase from Aspergillus oryzae expressed in Aspergillus oryzae carrageenan and processed Euchema seaweed cyclotetraglucose and cyclotetraglucose syrup isoamylase from Pseudomonas amyloderamosa magnesium sulfate phospholipase A1 from Fusarium venenatum expressed in Aspergillus oryzae sodium iron(III) ethylenediaminetetraacetic acid (EDTA) and steviol glycosides. Monographs on 8 teams of comparable flavouring brokers evaluated via the strategy for the security assessment of Flavouring brokers also are incorporated. This quantity additionally includes monographs summarizing the toxicological and consumption facts for the contaminants aflatoxins and ochratoxin A. This quantity and others within the WHO foodstuff ingredients sequence include details that's beneficial to those that produce and use nutrients ingredients and veterinary medicines and people concerned with controlling contaminants in foodstuff govt and nutrients regulatory officials business checking out laboratories toxicological laboratories and universities.

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2, 125 or 500 mg/l (five rats per group) or sodium chloride at 500 mg/l (10 rats per group) in their drinking-water. 5 mg/kg bw), which produces renal tubular necrosis in the rat. Following the exposure period, animals were sacrificed, the kidneys were prepared for histological examination and urinalysis was carried out. No significant differences in body weight changes or water consumption were seen between treatment groups. A significant increase in mean absolute and relative kidney weights was associated with the higher concentrations of sodium chlorite and sodium chloride at 30 and 90 days, but not at 180 days.

Small but statistically significant increases in time to preputial separation in the F1 pups of the 70 and 300 mg/l groups and in time to vaginal opening of the F1 pups of the 300 mg/l group were observed. Neither observation was found in the F2 pups. These changes were considered by the authors to be related to body weight. In the high-dose group, significant decreases in red blood cells, haemoglobin, haematocrit, mean corpuscular volume, mean corpuscular haemoglobin and mean corpuscular haemoglobin concentration were observed for all animals; in the 70 mg/l group, white blood cell count was significantly reduced.

The clinical evaluation did not show any treatment-related effects except for a statistically significant treatment group interaction in the mean corpuscular haemoglobin values for chlorite and chlorate. , 1981, 1982, 1984a). Individuals with G6PD deficiency have been identified as likely to be especially sensitive to the effects of oxidant stress such as that caused by chlorine dioxide and chlorite, because they have a reduced ability to form GSH. Three healthy adult males with G6PD deficiency were given 500 ml of sodium chlorite at a concentration of 5 mg chlorite/l daily for 12 weeks.

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