The AH Receptor in Biology and Toxicology by Raimo Pohjanvirta

By Raimo Pohjanvirta

This ebook presents an intensive and up to date evaluation of the aryl hydrocarbon receptor (AHR) and its specific twin function in toxicology and biology. The insurance contains epigenetic mechanisms, gene expression, reproductive and developmental toxicity, sign transduction, and transgenic animal versions. that includes an across the world well-known group of authors on the vanguard of AHR examine, this source offers a accomplished reference for readers attracted to realizing the complete spectrum of AHR, from easy recommendations, toxicology research, and types to polymorphism and similar ailments.

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Science 130, 1478–1479. 12. Nebert, D. W. and Bausserman, L. L. (1970). Genetic differences in the extent of aryl hydrocarbon hydroxylase induction in mouse fetal cell cultures. Journal of Biological Chemistry, 245, 6373–6382. 13. Nebert, D. W. and Gelboin, H. V. (1969). The in vivo and in vitro induction of aryl hydrocarbon hydroxylase in mammalian cells of different species, tissues, strains, and developmental and hormonal status. Archives of Biochemistry and Biophysics, 134, 76–89. 16 HISTORY OF RESEARCH ON THE AHR 14.

2009). The aryl hydrocarbon receptor: a perspective on potential roles in the immune system. Immunology, 127, 299–311. , Perez, G. , Pru, J. , Schlezinger, J. , Korsmeyer, S. , Casper, R. , Sherr, D. , and Tilly, J. L. (2001). Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals. Nature Genetics, 28, 355–360. Yao, E. F. and Denison, M. S. (1992). DNA sequence determinants for binding of transformed Ah receptor to a dioxinresponsive enhancer.

34. Denison, M. , Vella, L. , and Okey, A. B. (1986). Structure and function of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Species differences in molecular properties of the receptors from mouse and rat hepatic cytosols. Journal of Biological Chemistry, 261, 3987–3995. 35. Denison, M. S. and Wilkinson, C. F. (1985). Identification of the Ah receptor in selected mammalian species and induction of aryl hydrocarbon hydroxylase. European Journal of Biochemistry, 147, 429–435. 36. Gasiewicz, T.

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