By William B. Deichmann
Read or Download Toxicology and Occupational Medicine. Proceedings of the Tenth Inter-American Conference on Toxicology and Occupational Medicine, Key Biscayne (Miami), Florida, October 22–25, 1978 PDF
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Extra resources for Toxicology and Occupational Medicine. Proceedings of the Tenth Inter-American Conference on Toxicology and Occupational Medicine, Key Biscayne (Miami), Florida, October 22–25, 1978
Sample text
Denenber, V. C. 2. Fisher, R. (1953) The Design of Experiments, Oliver and Boyd, London. 31 MERCHANT MARINE INSPECTORS AND CHEMICALS LT. THOMAS J. HAAS Cargo and Hazardous Materials Division, United States Coast Guard, 400 Seventh Street, S. , Washington, D. C. 20590 ABSTRACT A major contribution to the uncertainty inherent in toxicologic data stems from the recognition that exposure to a single substance under carefully controlled conditions is generally most unrealistic. The Coast Guard has a group of approximately four hundred officers and warrant officers who are involved with the inspection of merchant vessels.
Non consistent reduction of lactation index. Reduced viability & sur vival indices. Reduced delivery rate litter size and 4-day survival. 25 mg/kg 100 mg/kg 250 mg/kg 150, 500 & 1500 ppm 4500 ppm 7,25,100 & 225 ppm 500 ppm 3 ppm 10 ppm 25 ppm Dieldrin49 Rat Dieldrin 50 Diquat 51 Rat Rat Fenchlorphos 52 Rat ? Weanling weight and lacta tion index reduced. Fertility index reduced. % survival to weaning reduced. Growth suppression in parents and pups noted. No reproductive effects. 1 & 1 ppm 2 ppm Pla 60 ppm* 125 ppm F,, Flb 500 ppm F 100 & 300 ppm 1000 ppm Flb Reduced survival to wean ing.
The second rationale is pragmatic. The essence of experimental research is to be able to reproduce one's findings in an independent replication. If a researcher 27 uses a scale about which he makes certain assumptions, carries out an experiment and obtains significant results, and if, in an independent replication he repeats his experimental findings, this is sufficient evidence to establish the validity of the measurement assumptions. Some statistical procedures require that assumptions be made about the popula tion to which one wishes to generalize.