Toxicology of Glutathione Transferases by Yogesh C. Awasthi

By Yogesh C. Awasthi

Crucial enzymes retaining human and different organisms from in all probability poisonous chemical substances, Glutathione S-transferases (GSTs) are principal to simple mechanisms equivalent to tension reaction and physiological features together with security opposed to lipid peroxidation. This booklet describes the position of GST in toxicology, concentrating on their pharmacologic and physiological roles and their relevance to organic toxicology. It covers constitution and serve as, gene rules, and those enzymes’ involvement in sign transduction. Reflecting present traits during this increasing learn sector, Toxicology of Glutathione Transferases is the one resource that info the tools of GST study.

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Characterization of rat spleen prostaglandin H Disomerase as a sigma-class GSH transferase, Biochem. J. 311, 739, 1995. 63. R. , Mammalian class Sigma glutathione S-transferases: catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D2 synthases, Biochem. J. 359, 507, 2001. 64. J. , Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson’s disease, Proc. Natl. Acad. Sci. USA 102, 8024, 2005. 65.

10, 35078, 1991. 22. R. , The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature, DNA Cell Biol. 12, 18629, 1993. 23. Mannervik, B. , Nomenclature for human glutathione transferases, Biochem. J. 282, 305, 1992. 24. , Fly fishing for GSTs: a unified nomenclature for mammalian and insect glutathione transferases, Chem. Biol. Interact. 133, 256, 2001. 25. R. , Biochemical and genetic characterization of a murine class Kappa glutathione S-transferase, Biochem.

A divergently organized, intronless gene family in Drosophila melanogaster, J. Biol. Chem. 268, 9737, 1993. 83. H. , Biochemical characterization of Drosophila glutathione S-transferases D1 and D21, J. Biol. Chem. 269, 27876, 1994. 84. C. , Drosophila glutathione S-transferase D27: functional analysis of two consecutive tyrosines near the N-terminus, Biochem. Biophys. Res. Commun. 209, 327, 1995. 85. Akgul, B. , Evidence for a stabilizer element in the untranslated regions of Drosophila glutathione S-transferase D1 mRNA, J.

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