By J. Turton, J. Hooson
The most important organs of the physique are pursuits for chemically-induced results in animals and people. This publication experiences the mechanisms of those poisonous results and the structure/functional adjustments which take place within the aim organ tissues for this reason.
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Additional resources for Target Organ Pathology - A Basic Text
And GRASSO, P. (1987) Nuclear enlargement produced in mouse skin by carcinogenic mineral oils, Journal of Applied Toxicology, 7, 289–295. A. R. (1986) Predicting carcinogenicity of petroleum distillation fractions using a modified Salmonella mutagenicity assay, Cell Biology and Toxicology, 2, 63–84. V. and MAY, K. (1994) An investigation of the main mutagenic components of a carcinogenic oil by fraction and testing in the modified Ames Assay, Journal of Applied Toxicology, 14, 173–179. GRASSO, P.
The pharynx is also the site of the lymphoid tissue of the tonsil, which is rich in antigen-presenting cells for the induction of the immune response. Salivary glands In the dog, ducts of the serous parotid and mucous zygomatic salivary glands open into the dorsal vestibule whereas the mixed (seromucous) mandibular (submaxillary), and mucous sublingual salivary glands, open at the sublingual caruncle, rostral to the frenulum of the tongue. THE DIGESTIVE SYSTEM I 29 Rodents have major and minor mucous sublingual salivary glands, mixed mandibular (submaxillary) glands, and serous parotid salivary glands.
Promoting properties are examined by giving mice a single treatment of a carcinogen such as DMBA followed by repeated 24 TARGET ORGAN PATHOLOGY: A BASIC TEXT treatments with the test material. If a substance is shown to have clear initiating and promoting activity it is likely to be a skin carcinogen. However, if either or both responses are weak, results are difficult to interpret. This is particularly the case with initiation as prolonged treatment with TPA alone can produce a low incidence of skin cancer.