Advances in Pharmacology by Silvio Garattini and Parkhurst A. Shore (Eds.)

By Silvio Garattini and Parkhurst A. Shore (Eds.)

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The kinin released from the zone of the axon reflex was named neurokinin. Bioassay and behavior toward various blocking agents distinguished it from bradykinin, according to Ramos et al. (1963a,b,c), but some other investigators disagree (Keele and Armstrong, 1964). The release of kinin in the forearm was not attributed by Chapnian to the function of sweat glands (R. H. Fox and Hilton, 1958), or to permeability changes (Hilton, 1963; Chapman and Goodell, 1964). , 1961). , 1960c; Keele and Armstrong, 1964) or intraarterial injection of bradykinin causes pain (R.

The kininogen was also lower in the blood of rabbits in anaphylactic shock (Lecomte, 1961; Diniz and Carvalho, 1963) or in dogs in eiidotoxin shock (Meyer and Werle, 1964), but ncphrcctomy in dogs had no effect (Fasciolo, 1962). IV. Kinins ( Bradykinin, Kallidin, Met-Lys-Bradykinin ) Bradykinin has the strange distinction among hypotensive peptides iii that it was synthesized before the final amino acid sequence of the natural product was established. Retween 1960 and 1964 more than 70 analogs of .

Possibly these fluids do not contain active kinins, but a kinin is released from kininogen when glass activates a kininogenase in the system (Keele and Armstrong, 1964). On the other hand, a material, which was probably active kinin, was found in the peritoneal cavity of mice during a “squirming” response (Whittle, 1964). Hot water treatment of the skin can also release a bradykinin-like substance subcutaneously. , 1959) (this certainly would be the first instance when hypnosis or another type of persuasion would hold back a kinin release).

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