By Donald M. Jerina (Eds.)
content material: Cytochrome P-450 : its function in oxygen activation for drug metabolism / R.W. Estabrook and J. Werringloer --
artificial types for the response phases of cytochrome P-450 / James P. Collman and Thomas N. Sorrell --
Biochemical reviews on drug metabolism : isolation of a number of types of liver microsomal cytochrome P-450 / M.J. Coon, J.L. Vermilion, K.P. Vatsis, J.S. French, W.L. Dean, and D.A. Haugen --
solution of a number of kinds of rabbit liver cytochrome P-450 / Eric F. Johnson and Ursula Muller-Eberhard --
Enantiomeric selectivity and perturbation of product ratios as tools for learning the multiplicity of microsomal enzymes / William F. Trager --
position of purified cytochrome P-448 and epoxide hydrase within the activation and detoxing of benzo[a]pyrene / W. Levin, A.W. wooden, A.Y.H. Lu, D. Ryan, S. West, A.H. Conney, D.R. Thakker, H. Yagi, and D.M. Jerina --
In vitro reactions of the diastereomeric 9,10-epoxides of (+) and ( --
)-trans-7,8-dihydroxy-7,8-dihydrobenzo-[a]pyrene with polyguanylic acid and proof for formation of an enantiomer of every diastereomeric 9,10-epoxide from benzo[a]pyrene in mouse epidermis / P.D. Moore, M. Koreeda, P.G. Wislocki, W. Levin, A.H. Conney, H. Yagi, and D.M. Jerina --
function of metabolic activation in chemical-induced tissue damage / Sidney D. Nelson, Michael R. Boyd, and Jerry R. Mitchell.
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G. , A r c h i v e s Biochem. Biophys. (1973), 157, 7-22. 56. G. , Archives Biochem. Biophys. (1974), 160, 230-245. 57. , Biochem. Biophys. Res. Comm. (1973) 54, 1255-1261. 58. W e r r i n g l o e r , J. , Pergamon P r e s s , Oxford, in press (1977). 59. , Biochem. Biophys. Res. Commun. (1974) 60, 695-702. 60. , Proc. N a t ' l . Acad. Sci. (USA), (1976) 73, 3381-3385. 61. , Ann. Rev. Biochemistry (1975) 44, 79-121. 62. M. , Mol. Pharm. (1972) 8, 204-214. 63. , X e n o b i o t i c a (1971) 1, 581-591.
Welle s t a b l i s h e d examples a r e d i a m a g n e t i c f e r r o u s c a r b o n y l d e r i v a t i v e s s i m i l a r t o s t a g e D i n F i g u r e 1. H i g h s p i n i r o n ( I I ) has f o u r u n p a i r e d e l e c t r o n s (S=2) and a c o v a l e n t r a d i u s t o o l a r g e t o be accommodated by t h e porphyrin core. Such h i g h s p i n f e r r o u s complexes have a s i n g l e a x i a l l i g a n d ( o v e r a l l 5 - c o o r d i n a t e ) and i r o n i s d i s p l a c e d out o f the plane o f the porphyrin r i n g a s , f o r example, i n deoxymyoglobin.
W e r r i n g l o e r , J. , Life Sciences (1973) 13, 1319-1330. 66. , J. Pharm. Exp. Therap. (1957) 119, 532-540. 67. H. , Biochem. Biophys. Res. Comm. (1965) 21, 78-85. 68. , Biochem. J. (1973) 131, 555-563. 69. J. , Biochem. Biophys. Res. Comm. (1970) 39, 530-537. 70. G. , D r o t t , H. , Academic P r e s s , New York (1977) in p r e s s . 71. W. and W e r r i n g l o e r , J. W. , Pergamon P r e s s , Oxford, in press (1977). 72. W e r r i n g l o e r , J. , in p r e p a r a t i o n . 73. , Annals New York Acad.