By Donald M. Jerina (Eds.)
content material: Cytochrome P-450 : its function in oxygen activation for drug metabolism / R.W. Estabrook and J. Werringloer --
artificial types for the response phases of cytochrome P-450 / James P. Collman and Thomas N. Sorrell --
Biochemical reviews on drug metabolism : isolation of a number of types of liver microsomal cytochrome P-450 / M.J. Coon, J.L. Vermilion, K.P. Vatsis, J.S. French, W.L. Dean, and D.A. Haugen --
solution of a number of kinds of rabbit liver cytochrome P-450 / Eric F. Johnson and Ursula Muller-Eberhard --
Enantiomeric selectivity and perturbation of product ratios as tools for learning the multiplicity of microsomal enzymes / William F. Trager --
position of purified cytochrome P-448 and epoxide hydrase within the activation and detoxing of benzo[a]pyrene / W. Levin, A.W. wooden, A.Y.H. Lu, D. Ryan, S. West, A.H. Conney, D.R. Thakker, H. Yagi, and D.M. Jerina --
In vitro reactions of the diastereomeric 9,10-epoxides of (+) and ( --
)-trans-7,8-dihydroxy-7,8-dihydrobenzo-[a]pyrene with polyguanylic acid and proof for formation of an enantiomer of every diastereomeric 9,10-epoxide from benzo[a]pyrene in mouse epidermis / P.D. Moore, M. Koreeda, P.G. Wislocki, W. Levin, A.H. Conney, H. Yagi, and D.M. Jerina --
function of metabolic activation in chemical-induced tissue damage / Sidney D. Nelson, Michael R. Boyd, and Jerry R. Mitchell.
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Extra resources for Drug Metabolism Concepts
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Welle s t a b l i s h e d examples a r e d i a m a g n e t i c f e r r o u s c a r b o n y l d e r i v a t i v e s s i m i l a r t o s t a g e D i n F i g u r e 1. H i g h s p i n i r o n ( I I ) has f o u r u n p a i r e d e l e c t r o n s (S=2) and a c o v a l e n t r a d i u s t o o l a r g e t o be accommodated by t h e porphyrin core. Such h i g h s p i n f e r r o u s complexes have a s i n g l e a x i a l l i g a n d ( o v e r a l l 5 - c o o r d i n a t e ) and i r o n i s d i s p l a c e d out o f the plane o f the porphyrin r i n g a s , f o r example, i n deoxymyoglobin.
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