Drug Metabolism Concepts by Donald M. Jerina (Eds.)

By Donald M. Jerina (Eds.)

content material: Cytochrome P-450 : its function in oxygen activation for drug metabolism / R.W. Estabrook and J. Werringloer --
artificial types for the response phases of cytochrome P-450 / James P. Collman and Thomas N. Sorrell --
Biochemical reviews on drug metabolism : isolation of a number of types of liver microsomal cytochrome P-450 / M.J. Coon, J.L. Vermilion, K.P. Vatsis, J.S. French, W.L. Dean, and D.A. Haugen --
solution of a number of kinds of rabbit liver cytochrome P-450 / Eric F. Johnson and Ursula Muller-Eberhard --
Enantiomeric selectivity and perturbation of product ratios as tools for learning the multiplicity of microsomal enzymes / William F. Trager --
position of purified cytochrome P-448 and epoxide hydrase within the activation and detoxing of benzo[a]pyrene / W. Levin, A.W. wooden, A.Y.H. Lu, D. Ryan, S. West, A.H. Conney, D.R. Thakker, H. Yagi, and D.M. Jerina --
In vitro reactions of the diastereomeric 9,10-epoxides of (+) and ( --
)-trans-7,8-dihydroxy-7,8-dihydrobenzo-[a]pyrene with polyguanylic acid and proof for formation of an enantiomer of every diastereomeric 9,10-epoxide from benzo[a]pyrene in mouse epidermis / P.D. Moore, M. Koreeda, P.G. Wislocki, W. Levin, A.H. Conney, H. Yagi, and D.M. Jerina --
function of metabolic activation in chemical-induced tissue damage / Sidney D. Nelson, Michael R. Boyd, and Jerry R. Mitchell.

Show description

Read or Download Drug Metabolism Concepts PDF

Similar toxicology books

Handbook of Pesticide Toxicology, Volumes 1-2 (3rd Edition)

The instruction manual of Pesticide Toxicology is a entire, two-volume reference consultant to the houses, results, and law of insecticides that offers the newest and such a lot whole info to researchers investigating the environmental, agricultural, veterinary, and human-health affects of pesticide use. Written by way of foreign specialists from academia, govt, and the non-public region, the guide of Pesticide Toxicology is an in-depth exam of severe matters on the topic of the necessity for, use of, and nature of chemical substances utilized in glossy pest administration. This up-to-date 3rd variation includes at the book's culture of serving because the definitive reference on pesticide toxicology and recognizies the seminal contribution of Wayland J. Hayes, Jr. , co-Editor of the 1st edition.

Feature: offers a complete examine all points of pesticide toxicology in a single reference paintings.
Benefit: Saves researchers time in fast having access to the very newest definitive info on toxicity of particular insecticides in place of looking through millions of magazine articles.

Feature: transparent exposition of probability identity and dose reaction relationships in every one bankruptcy that includes pesticide brokers and actions
Benefit: Connects the experimental laboratory effects to real-life functions in human wellbeing and fitness, animal healthiness and the environment.

Feature: All significant sessions of pesticide considered.
Benefit: offers relevance to a much wider number of researchers who're accomplishing comparative paintings in insecticides or their overall healthiness impacts.

Feature: varied routes of publicity significantly evaluated.
Benefit: Connects the loop among publicity and destructive impacts to those that are studying the impacts of insecticides on people or wildlife.

Chemical Evolution: The Biological System of the Elements

This ebook is written for researchers and scholars drawn to the functionality and position of chemical parts in organic or environmental structures. specialists have lengthy recognized that the Periodic process of parts (PSE) presents simply an insufficient chemical description of parts of organic, environmental or medicinal significance.

Animal Clinical Chemistry - A Practical Handbook for Toxicologists and Biomedical Researchers

10+ Years of Updates when you consider that First variation newbies to the animal medical chemistry and toxicology fields fast locate that a similar principles of human medication don't regularly follow. Following within the footsteps of its standard-setting first variation, Animal scientific Chemistry: a pragmatic instruction manual for Toxicologists and Biomedical Researchers, moment version collates info commonly dispersed in journals and ebook chapters, concentrating on the main proper literature to experimental toxicology and its contrast from human drugs.

Environmental Toxicology Assessment

Size of the level of the poisonous insult attributable to the substance concerned is of significance whilst project an environmental toxicology evaluation. this article outlines a number of the size thoughts which have been lately constructed and

Extra resources for Drug Metabolism Concepts

Sample text

G. , A r c h i v e s Biochem. Biophys. (1973), 157, 7-22. 56. G. , Archives Biochem. Biophys. (1974), 160, 230-245. 57. , Biochem. Biophys. Res. Comm. (1973) 54, 1255-1261. 58. W e r r i n g l o e r , J. , Pergamon P r e s s , Oxford, in press (1977). 59. , Biochem. Biophys. Res. Commun. (1974) 60, 695-702. 60. , Proc. N a t ' l . Acad. Sci. (USA), (1976) 73, 3381-3385. 61. , Ann. Rev. Biochemistry (1975) 44, 79-121. 62. M. , Mol. Pharm. (1972) 8, 204-214. 63. , X e n o b i o t i c a (1971) 1, 581-591.

Welle s t a b l i s h e d examples a r e d i a m a g n e t i c f e r r o u s c a r b o n y l d e r i v a t i v e s s i m i l a r t o s t a g e D i n F i g u r e 1. H i g h s p i n i r o n ( I I ) has f o u r u n p a i r e d e l e c t r o n s (S=2) and a c o v a l e n t r a d i u s t o o l a r g e t o be accommodated by t h e porphyrin core. Such h i g h s p i n f e r r o u s complexes have a s i n g l e a x i a l l i g a n d ( o v e r a l l 5 - c o o r d i n a t e ) and i r o n i s d i s p l a c e d out o f the plane o f the porphyrin r i n g a s , f o r example, i n deoxymyoglobin.

W e r r i n g l o e r , J. , Life Sciences (1973) 13, 1319-1330. 66. , J. Pharm. Exp. Therap. (1957) 119, 532-540. 67. H. , Biochem. Biophys. Res. Comm. (1965) 21, 78-85. 68. , Biochem. J. (1973) 131, 555-563. 69. J. , Biochem. Biophys. Res. Comm. (1970) 39, 530-537. 70. G. , D r o t t , H. , Academic P r e s s , New York (1977) in p r e s s . 71. W. and W e r r i n g l o e r , J. W. , Pergamon P r e s s , Oxford, in press (1977). 72. W e r r i n g l o e r , J. , in p r e p a r a t i o n . 73. , Annals New York Acad.

Download PDF sample

Rated 4.35 of 5 – based on 33 votes