Nutritional Toxicology Volume 2 by John N. Hathcock

By John N. Hathcock

Dietary Toxicology, quantity II, discusses some of the interactions among dietary phenomena and toxicologic methods. It addresses specific topics that experience develop into considerably extra very important in the course of the improvement of recent wisdom, major raises in wisdom, or elevated wisdom of power results on human overall healthiness and wellbeing and fitness. the results of such wisdom have impression on easy learn, toxicity checking out, public wellbeing and fitness, foodstuff, and agriculture courses, and foodstuff safeguard rules.
The publication starts with a assessment of the position and value of macro- and micronutrients on detoxing techniques of international compounds after absorption. this is often by way of separate chapters on mixed-function oxidation within the liver; the metabolic and dietary results of ethanol; the results of malnutrition on drug metabolism; interplay of nutrient consumption with DNA and chromatin; and the way such interactions may possibly have an effect on the method of toxicogenesis within the nucleus. next chapters hide mutagens in cooked meals; nutrition sensitivities; anatomical, cardiovascular, and behavioral results of nutritional caffeine; the toxicology of nutritional tin, aluminum, and selenium; and the toxicology of insecticides in meals.

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Extra info for Nutritional Toxicology Volume 2

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Res. Commun. Chem. Pharmacol. 1 1 , 3 1 - 3 8 . Bus, J. , Aust, S. D . , and Gibson, J. E. (1976). Paraquat toxicity: Proposed mechanism of action involving lipid peroxidation. Environ. Health Perspect. 1 6 , 139-146. Calabrese, E. J. (1979). Should the concept of the recommended dietary allowance be altered to incorporate interactive effects of ubiquitous pollutants? Med. Hypotheses 5 , 1273-1285. Campbell, T. , and Hayes, J. R. (1974). Role of nutrition in the drug metabolizing enzyme system.

Using antipyrine and theophylline t V 2 in plasma, Alvares et al. (1976), Kappas et al. (1976), and Anderson et al. (1982) have found that a high- 14 Mohsen Meydani carbohydrate diet had no significant effect on drug metabolism as compared to a normal diet in humans. Sonawane et al. (1983) have indicated that the relative quantities of carbohydrate and fat in the diet are more important than the quality of carbohydrate in the modification of MFO system. A specific role for carbohy­ drate in the detoxification processes is not established yet.

Bjelke, E. (1975). Dietary vitamin A and human lung cancer. Int. J. Cancer 1 5 , 5 6 1 - 5 6 5 . 1 . , and Hochman, D. (1984). Effects of vitamin C on caffeine pharmacokinetics in young and aged guinea pigs. Drug-Nutr. Interact. 2, 2 4 3 - 2 5 5 . Blum, R. , and Carter, S. K. (1974). Adriamycin—A new anti-cancer drug with significant clinical activity. Ann. Intern. Med. 8 0 , 249. Boyd, Ε. M . , and Krupa, V. (1970). Protein-deficient diet and diuron toxicity. Agric. Food Chem. 1 8 , 1104-1107.

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